| Abstract [eng] |
Industrially produced oral tablets have side effects that are complained of by patients of all ages, as well as people who need different doses of medication. It has been found that 35-40% of all deaths are caused by irresponsible drug uses. The aim of this work is to show the advantages and possibilities of additive manufacturing in the personalized medicines. The research study presents comparative studies between hand-made and 3D-printed tablets and describes the formed theophylline tablets by selecting different compositions of sorbitol, lactose, mannitol and polyvinyl alcohol. The analysis of the mechanical properties of the produced theophylline tablets showed that 3D-printed tablets are more resistant to abrasion. The mechanically strongest hand-made tablets are when 35% polyvinyl alcohol (83K) and 20% lactose are used. Tablets made by 3D printing are the strongest when using 40% polyvinyl alcohol (85K) and 15% sorbitol, as well as using 35% polyvinyl alcohol (20-30K) and 20% lactose.Analysis of Fourier transform infrared spectra, thermogravimetric analysis thermograms and X-ray diffractometry data showed that the molecules of the materials are stable at a processing 3D printing temperature of 30 oC. No specific changes were observed in the structures of the compounds and during the formation of the tablets, the chemical composition did not changed. The analysis of drugs release shows that 61,8% of theophylline was released within 30 minutes and sudden release of the drug was avoided. |
