| Title |
Markovian model of the voltage gating of connexin-based gap junction channels |
| Translation of Title |
Plyšinės jungties savybių modeliavimas naudojant Markovo grandines. |
| Authors |
Sakalauskaite, A ; Pranevicius, H ; Pranevicius, M ; Bukauskas, F |
| DOI |
10.5755/j01.eee.111.5.367 |
| Full Text |
|
| Is Part of |
Elektronika ir elektrotechnika.. Kaunas : Technologija. 2011, Nr. 5, p. 103-106.. ISSN 1392-1215. eISSN 2029-5731 |
| Abstract [eng] |
Gap junction (GJ) channels, which are formed of a connexin (Cx) protein provide pathways through which ions and small molecules are exchanged between adjacent cells. GJs co-ordinate the cellular activity in tissues by synchronizing their electrical activity and allowing a direct cell-to-cell chemical signaling. Electrically gap junctions present nonlinear conductance that depends on transjunctional voltage and can be modulated by chemical reagents and ions, such as pH, Ca2+, etc. Here, we describe the model of the voltage gating of gap junctions using Markovian formalism. The results obtained using a stationary Markov model are well comparable with those obtained using a stochastic/imitational model of voltage gating. |
| Published |
Kaunas : Technologija |
| Type |
Journal article |
| Language |
English |
| Publication date |
2011 |
| CC license |
|
