Title Investigation of properties of radiosensitive hydrogels /
Translation of Title Jonizuojančiajai spinduliuotei jautrių hidrogelių savybių tyrimas.
Authors Staliulionytė, Miglė
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Pages 77
Keywords [eng] 3D dosimetry ; polymer gels dosimetry ; MAGIC ; nanoparticles
Abstract [eng] Polymer gel dosimetry is widely used for 3D dose distribution investigations, because dose gels are near tissue equivalent, dose sensitive and represent dosimeter and phantom at once. Polymer gels are perfect tool for investigation of the absorbed dose enhancement effects in tumor volume. These effects are explored in radiotherapy and can be achieved incorporating nanoparticles into the tumor. Incorporated nanoparticles enhance radiation absorption capability of irradiated gels. Since the gels are tissue equivalent polymer gels may be used for in vitro dose investigations. The aim of this research was to investigate photon irradiated MAGIC (methacrylic acid in gelatin initiated by copper) gels of different concentrations containing silver nanoparticles. Properties of dose gels were investigated using film dosimetry system, UV-VIS spectroscopy and semiconductor detectors. It was shown, that incorporation of silver nanoparticles in MAGIC gels led to better radiation absorption as compared to MAGIC gels without nanoparticles. Additionally the search for optimal methacrylic acid concentration was performed in order to sustain stable and homogeneous gel consistency. It was found that the gel, containing methacrylic acid concentration of 7% was mostly sensitive for irradiation. The impact of silver nanoparticles on radiation absorption properties of irradiated gels was also examined in this research. Experimental results revealed that the best absorption of ionizing radiation was recorded in MAGIC (NPs 2mM) gel and X-ray absorption coefficient of this gel was 26.6 % at 5Gy. The highest X-ray absorption at 2 Gy was observed in MAGIC (NPs 20mM) gel. It was also found that additional nanoparticles have been produced through radiolysis in irradiated gels. These nanoparticles contributed to the absorbed dose enhancement by ~1.6%.
Dissertation Institution Kauno technologijos universitetas.
Type Master thesis
Language English
Publication date 2018