| Title |
Development and evaluation of 3D-printed PLA/PHA/PHB/HA composite scaffolds for enhanced tissue-engineering applications / |
| Authors |
Raziyan, Motahareh Sadat ; Palevicius, Arvydas ; Perkowski, Dariusz ; Urbaite, Sigita ; Janusas, Giedrius |
| DOI |
10.3390/jcs8060226 |
| Full Text |
|
| Is Part of |
Journal of composites science.. Basel : MDPI. 2024, vol. 8, iss. 6, art. no. 226, p. 1-16.. ISSN 2504-477X |
| Keywords [eng] |
bone graft ; tissue engineering ; polymeric composite ; 3D printing |
| Abstract [eng] |
Recently, tissue engineering has been revolutionised by the development of 3D-printed scaffolds, which allow one to construct a precise architecture with tailored properties. In this study, three different composite materials were synthesised using a combination of polylactic acid (PLA), polyhydroxyalkanoates (PHA), poly(3-hydroxybutyrate) (PHB) and hydroxyapatite (HA) in varying weight percentages. Morphological properties were evaluated by scanning electron microscopy showing a uniform distribution of HA particles throughout the matrix, indicating good compatibility between the materials. Furthermore, the printed scaffolds were tested under pressure using a load cell to examine mechanical strength. Scanning electron microscopy (SEM) analysis showed favorable dispersion, biological compatibility together with enhanced bioactivity within the PHB/PHA/PLA/HA composite matrixes. Thus, this paper demonstrates the successful design and implementation of these composite structures for tissue-engineering applications and highlights the effective development of biocompatible scaffold designs with improved functionality. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
