| Abstract [eng] |
One of the modern world health issues is coronary artery disease. Each year worldwide, due to this problem, around 7 million people’s lives are lost, and 129 million people cannot continue the life that they were adjusted to. In order to prevent such consequence, cardiac-pulmonary bypass (CPB) surgery is used to restore previous vascular blood flow by adding shunt for carotid arteries. The complications of CPB surgery are that around 50% of patients develop postoperative cognitive dysfunction (POCD). POCD is a state with impaired cognition, awareness, attention, and perception compared to the preoperative state. In the current global market of medical devices and technologies, there is no equipment, which would allow to determine optimal arterial blood pressure faster than in 5–20 minutes. The idea was to modulate a blood flow of heart and lung machine by rectangular pulses (period of the pulses one minute or less) in order to continuously monitor cerebral autoregulation (CA) transient functions. Such mode of heart and lung machine is novel and has never been clinically tested. The prospective clinical study has been performed in order to clinically validate proposed novel heart and lung machine operation mode and evaluate an added value of CA transient function continuous real-time monitoring in the development of methodology and technology for human brain protection against functional brain damage during cardiac bypass surgery. |
