| Abstract [eng] |
The development of modern biosensors requires technologies for the development of micromechanical liquid devices and the positioning and control of bioparticles in them. This is a prerequisite for sensors operating on the principle of single particle sensing. Therefore, such micromechanical devices create nano/micro spaces into which bioparticles for the analysis are positioned. Therefore, it is important to develop micromechanical systems with nano/microspaces at the nano/micrometric level that can be used to develop nano/micro bioparticle traps and storages as well as biosensors operating on this basis. This dissertation presents entire microfluidic acoustophoresis device done from a piezoelectric nanocomposite with piezoelectric properties at the micrometric level, which would allow for even more efficient generation of bulk acoustic waves, meaning the control of bioparticles. Traditionally, acoustophoresis devices are made of silicon, glass, PMMA, PDMS, and other materials. Biocompatibility with lead particles is a problem in the manufacture of microfluidic devices from piezoceramic nanocomposite. Therefore, another challenge of the dissertation was to develop a lead-free piezoelectric nanocomposite with a piezoelectric effect at the micrometric level by replacing lead with barium. |
