| Abstract [eng] |
Various indole isosteres, although not commonly found in the wild, are synthesized and, like bisindoles, have a wide variety of biological activities that are applicable in medicinal chemistry. These compounds have antiviral, anti-inflammatory, anticancer, anthelmintic, antioxidant, various kinase inhibitory and other properties. Given the diversity of biological properties of bisindoles, it is surprising that there are very few synthesized bisindole isosteres. The aim of this work is to synthesize various substituted bisindole isostere compounds that are likely to have biological activity according to detailed analysis of the literature of biologically active indole isostere derivatives. Intermediates for bis-7-azaindoles were obtained first, with aromatic aldehydes attached to various azaindoles via a C-3 carbon atom. In a subsequent reaction, a second molecule of azaindole was added to the resulting compounds. Variously substituted symmetric and asymmetric bis-7-azaindole compounds were thus obtained. The structures of the intermediates and final products were confirmed by detailed analysis of NMR, IR, MS, and HRMS spectra. |
