| Abstract [eng] |
Changing the surrounding environment causes rapid appearance of a new bacterial strain as well as the growing resistance of old ones to pharmaceuticals therefore, the search for new biologically active drugs is particularly important. Five- and six-membered heterocyclic compounds and their derivatives possess great potential for the synthesis of new biologically active compounds. They are involved in important biochemical processes that take place in the living organisms, thus ensuring normal vital functions. Synthetic thiazole derivatives with a broad spectrum of biological activity are of particular importance. They show a broad spectrum of biological properties. Many biologically active compounds contain a β-alanine moiety, which allows them to be used in the development of pharmaceutically important preparations. N-substituted-β-amino acids are widely used for the synthesis of azetidine, quinoline, imidazole, pyridine derivatives. In this work, hydrogenated aminothiazole derivatives were obtained by Hantzsch synthesis. Aminotiazole derivatives with aliphatic and aromatic substituents were synthesized by reacting the starting materials with different halocarbonyl compounds, respectively. Selective synthesis of mono- and dihydrazides and their cyclization were performed. Using Vilsmeier's reagent, 5-formylthiazoles were obtained. Bisphenylmethanes synthesized by the MacDonald condensation method between aromatically substituted aminothiazoles and aromatic aldehydes. |
