| Title |
Development of bone equivalent 3D printing composites for patient specific quality assurance in radiotherapy / |
| Authors |
Jreije, Antonio ; Adlienė, Diana |
| ISBN |
9786090705575 |
| Full Text |
|
| Is Part of |
NBCM 2020: international conference on nanostructured bioceramic materials, 1-3 December 2020, Vilnius, Vilnius University: conference book.. Vilnius : Vilnius Univerity Press, 2020. p. 39.. ISBN 9786090705575 |
| Keywords [eng] |
bone equivalent ; 3D printing ; composites ; radiotherapy |
| Abstract [eng] |
Additive manufacturing or 3-dimensional printing technology has gained popularity in recent years with a widespread application in medicine (e.g. implants or orthopaedic appliances, prostheses, surgical guides, etc). Given the flexibility and low cost of 3D printing, it is used for the creation of patient specific phantoms for radiotherapy quality assurance [1]. Previous publications demonstrated that commercially available 3D printing polymers can replicate soft tissues with high degree of accuracy. However, these studies failed to take into account that the human body is composed of different types of tissues which have a wide range of radiation attenuation and HU values. This work aims at investigating the feasibility of creating a 3D printing composite with bone equivalent properties for future application in individualized anthropomorphic phantom. Specific features of the developed 3D printed materials i.e. tissue equivalency and X-ray attenuation were characterised. The methodology presented in this study was to dope the commercially available 3D printing material High Impact Polystyrene (HIPS) with selected Tantalum metal powder (Ta, Z = 73) at appropriate ratio in order to achieve mass attenuation profiles equivalent to that of the bone. The weight percentage of the doping powder can be calculated theoretically in first approximation using mathematical modeling (NIST XCOM database) [2]. The x-ray attenuation properties were investigated in the energy range 50-150 keV which is relevant for phantom based analysis using Orthovoltage X-ray therapy. Using this approach, it was found that X- ray attenuation similar to that of bones can be achieved by the the addition of 0,47 wt % Ta powder to HIPS. In order to verify the results of the modeling, the attenuation properties of HIPS samples doped with different weight percentage of Ta (0.28%, 0.47%, 0.74% and 1.4%) was measured experimentally. Using 3D printer Zortrax 300M, experimental samples were manufactured by applying layer-by-layer printing technique while depositing Ta (powder, - 100 mesh, Sigma Aldrich) between the printed layers. Experimental evaluation of the physical density and attenuation properties of the printed samples provided promising results for their application as a bone equivalent material. However, inhomogeneity of powder distribution was identified and will be discussed in future work dedicated for the fabrication of Ta doped HIPS filament for 3D printing. [...]. |
| Published |
Vilnius : Vilnius Univerity Press, 2020 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
