| Title |
Synthesis and antimicrobial activity of N-substituted-β-amino acid derivatives containing 2-hydroxyphenyl, benzo[b]phenoxazine and quinoxaline moieties / |
| Authors |
Mickevičienė, Kristina ; Baranauskaitė, Rūta ; Kantminienė, Kristina ; Stasevych, Maryna ; Komarovska-Porokhnyavets, Olena ; Novikov, Volodymyr |
| DOI |
10.3390/molecules20023170 |
| Full Text |
|
| Is Part of |
Molecules.. Basel : MDPI. 2015, vol. 20, iss. 2, p. 3170-3189.. ISSN 1420-3049 |
| Keywords [eng] |
heterocycles ; 1 ; 4-naphthoquinone derivatives ; hydrazones ; antibacterial activity ; fungicides |
| Abstract [eng] |
3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5- methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2015 |
| CC license |
|
