| Abstract [eng] |
Modification of the hydrazine moiety of 3-[(2-carboxyethyl) (4-methylphenyl) amino] propanoic acid hydrazide extends the synthesis of potentially biologically active derivatives. Condensation reactions of dihydrazide with heterocyclic acetyl-containing compounds to give hydrazones were performed. Functionalization of synthesized potassium dithiocarbazate with hydrochloric acid was found to form functionalized 1,3,4-oxadiazole derivatives. In the reaction of the dihydrazide with methyl isothiocyanate or phenyl isothiocyanate gives the corresponding thiosemicarbazides, which are easily cyclized to 1,2,4-triazole-3-thione derivatives in an alkaline medium. In three-component reactions, S-alkylated 1,2,4-triazolethionines were synthesized from hydrazide, haloalkane, and the corresponding base (e.g. K2CO3, KOH, TEA). The spectra of the obtained compounds were compared with those of similar structure previously synthesized by researchers, but with different radicals. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, and IR spectroscopy, HRMS spectrometry methods. |
