| Abstract [eng] |
Amino acid derivatives exhibit a wide range of biological properties. Due to their strong antioxidant, antibacterial and antiviral activity, the compounds have been widely used as drugs. Previous studies have shown that compounds of amino acids containing a pyrazole pharmacophore demonstrated enhanced results of biological effects. The important properties of the derivatives are determined by the exact amino acid sequence in the chain and the configuration of the compounds. The incorporation of halogens into the structure has been found to enhance the anticancer activity of the compounds. The growing need for new and more complex amino acid derivatives required manufacturing compounds by efficient synthetic strategies. Therefore, the search for new more versatile and low–cost reagents becomes a great challenge. For this reason, in this work a novel amino acid derivatives, containing a pyrazole ring, have been synthetized. The synthesis of amide bond formation was optimized and the structures of the products were confirmed by 1H and 13C NMR, IR and Mass spectrometry analysis methods. Test of the specific optical rotation angle was performed to confirm the chirality. The biological properties of novel compounds were investigated in biotechnology laboratory at KTU Faculty of Chemical Technology. 1H-pyrazol-5-yl-piperidine-1-carboxylates exhibited radical‘s scavenging, antioxidant, reductive and antibacterial properties. |
