Title Comparative study of novel noninvasive cerebral autoregulation volumetric reactivity indices reflected by ultrasonic speed and attenuation as dynamic measurements in the human brain /
Authors Bajpai, Basant K ; Zakelis, Rolandas ; Deimantavicius, Mantas ; Imbrasiene, Daiva
DOI 10.3390/brainsci10040205
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Is Part of Brain sciences.. Basel : MDPI. 2020, vol. 10, iss. 4, art. no. 205, p. 1-12.. ISSN 2076-3425
Keywords [eng] ABP = arterial blood pressure ; CA = cerebrovascular autoregulation ; CBF = cerebral blood flow ; CPP = cerebral perfusion pressure ; ICP = intracranial pressure ; PRx = pressure reactivity index ; TOF = time-of-flight ; VRx = volumetric reactivity index
Abstract [eng] This is a comparative study of two novel noninvasive cerebrovascular autoregulation (CA) monitoring methods based on intracranial blood volume (IBV) changes in the human brain. We investigated the clinical applicability of the new volumetric reactivity index (VRx2), reflected by intracranial ultrasonic attenuation dynamics for noninvasive CA monitoring. The CA was determined noninvasively on 43 healthy participants by calculating the volumetric reactivity index (VRx1 from time-of-flight of ultrasound, VRx2 from attenuation of ultrasound). The VRx was calculated as a moving correlation coefficient between the arterial blood pressure and noninvasively measured IBV slow waves. Linear regression between VRx1 and VRx2 (averaged per participants) showed a significant correlation (r = 0.731, p < 0.0001, 95% confidence interval [0.501-0.895]) in data filtered by bandpass filtering. On the other hand, FIR filtering demonstrated a slightly better correlation (r = 0.769, p < 0.0001, 95% confidence interval [0.611-0.909]). The standard deviation of the difference by bandpass filtering was 0.1647 and bias -0.3444; and by FIR filtering 0.1382 and bias -0.3669. This comparative study showed a significant coincidence of the VRx2 index compared to that of VRx1. Hence, VRx2 could be used as an alternative, cost-effective noninvasive cerebrovascular autoregulation index in the same way as VRx1 values are used.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2020
CC license CC license description