| Title |
Sonoporation dosimetric evaluation from ultrasound signals attenuated by microbubbles / |
| Authors |
Maciulevičius, Martynas ; Tamošiūnas, Mindaugas ; Jurkonis, Rytis ; Venslauskas, Mindaugas ; Šatkauskas, Saulius |
| Full Text |
|
| Is Part of |
Biomedical engineering 2014: proceedings of the 18th international conference, 27-28 November, 2014, Kaunas, Lithuania / Kaunas University of Technology Biomedical Engineering Institute... Kaunas : Technologija. 2014, p. 71-75.. ISSN 2029-3380 |
| Keywords [eng] |
sonoporation ; ultrasound ; microbubbles ; drug delivery ; dosimetry |
| Abstract [eng] |
New dosimetric estimate for ultrasound and microbubble assissted molecular delivery method (sonoporation) is presented in current study. Ultrasound signals, attenuated by cavitating microbubbles, were quantified as amplitude vs. time integral – „AMP dose“. The latter metric accurately (R2=0.97) predicts irreversible sonoporation to CHO cells, induced by microbubble cavitation in vitro, and holds promising prospects for future applications to dosimetric evaluation of molecular delivery. |
| Published |
Kaunas : Technologija |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2014 |
