| Title |
4-(1Н-Benzimidazol-2-il)-1-[3-(trifluormetil)fenil]-2-pirolidinono sintezė ir transformacijos |
| Another Title |
Synthesis and transformation of 4-(1H-benzimidazol-2-yl)1-[3-trifluoromethyl)phenyl]-2-pyrrolidinone. |
| Authors |
Vaickelionienė, R ; Sapijanskaitė, B ; Mickevičius, V |
| DOI |
10.5755/j01.ct.60.2.1949 |
| Full Text |
|
| Is Part of |
Cheminė technologija.. Kaunas : KTU. 2012, Nr. 2, p. 37-43.. ISSN 1392-1231. eISSN 2029-719X |
| Abstract [eng] |
A study of the chemical transformations of 4-(1Н-benzimidazol- 2-yl)-1-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone was carried out. The N-substituted benzimidazole derivative was synthesized by alkylation of 1-(3-fluoromethylphenyl)-3- (1H-benzimidazol-2-yl)-5-oxopyrrolidine with ethyl chloroacetate in toluene in the presence of potassium carbonate and a catalytic amount of tetrabutylammonium iodide. Carbohydrazide was obtained by reaction of the ester with hydrazine hydrate in refluxing 2-propanol. The hydrazones were synthesized by condensation of hydrazide with aromatic aldehydes. In the reaction with acetone and ethylmethylketone, the corresponding hydrazones were obtained. In analogous reactions with diketones (2,4-pentanedione and 2,5-hexanedione), cyclic compounds with pyrrole and pyrazole moieties were synthesized. The results of this work have indicated the possibility to synthesize a wide range of 1,2-disubstituted benzimidazoles containing 5-оxо-1-(3-trifluoromethylphenyl)pyrrolidine and hydrazone, pyrrole, pyrazole, benzimidazole, or triazine fragments. |
| Published |
Kaunas : KTU |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2012 |
| CC license |
|
