| Title |
Piece-linear aggregates for formal specification and simulation of hybrid systems: pharmacokinetics patient-controlled analgesia / |
| Translation of Title |
Hibridinių sistemų formalus specifikavimas ir imitavimas atkarpomis tiesiniais agregatais: paciento valdomos analgezijos farmakokinetinis modelis. |
| Authors |
Pranevicius, H ; Simaitis, L ; Pranevicius, M ; Pranevicius, O |
| DOI |
10.5755/j01.eee.110.4.293 |
| Full Text |
|
| Is Part of |
Elektronika ir elektrotechnika.. Kaunas : Technologija. 2011, Nr. 4, p. 81-84.. ISSN 1392-1215. eISSN 2029-5731 |
| Abstract [eng] |
Piece Linear Aggregates formalism (PLA) for specification and simulation of hybrid systems, when continuous components are described in ordinary differential equations (ODEs). PLA is used to create Quantized State System (QSS) model. QSS is integration based method, created for ODE solving. Since QSS method first was introduced for use in Discreet Event Systems (DEVS) formalism, we adapted it for PLA formalism, which is fundamentally consanguineous to DEVS formalism. Pharmacokinetics model is used as example of hybrid system. Pharmacokinetics is a branch of pharmacology which describes administered drug absorption and distribution in human body. In pharmacokinetics drug distribution is described using ODE. In order to use drug injection in pharmacokinetics model, we have to modify standard QSS model and add some specific capabilities. Result: modified QSS method was obtained and used for pharmacokinetic model specification. Simulation of morphine concentration in plasma was performed using real pharmacokinetics data to test Patient-Controlled Analgesia (PCA) method effectiveness. |
| Published |
Kaunas : Technologija |
| Type |
Journal article |
| Language |
English |
| Publication date |
2011 |
| CC license |
|
