| Abstract [eng] |
A series of novel 3-bromoaniline-based heterocyclic derivatives was synthesized and structurally characterized using 1H and 13C NMR spectroscopy, FTIR analysis, and elemental analysis. The compounds were divided into three main classes: 2-aminothiazole derivatives 5a–h, chalcone derivatives 9a–k, and imidazole-2-thione derivatives 11–17a,b. Chemical transformations of the obtained intermediate compounds 4, 8, and 11 were carried out, enabling the stepwise introduction of the desired functional fragments into the molecular structure. The chalcone derivatives 9a–k were synthesized by the condensation of 5-acetylthiazole 8 with various substituted aldehydes, allowing for systematic structural modification. |
