| Title |
2,3,3-trimetilindolin-2-karbonitrilų sintezė ir jų savybių tyrimas / |
| Translation of Title |
Synthesis of 2,3,3-trimethylindolin-2-carbonitriles and investigation of their properties. |
| Authors |
Trofimovas, Darius |
| Full Text |
|
| Pages |
52 |
| Keywords [eng] |
3H-indoles ; α-aminonitriles ; reduction ; hydrolysis |
| Abstract [eng] |
The search for pharmacologically active compounds is one of the main factors leading to advancements in organic chemistry. Nowadays, drugs of racemic mixtures are losing interest and the focus is being put on synthesis of desired stereostructure compounds. 1,2-diamines are valuable compounds which find wide applications in medicine, organic synthesis, racemates distribution or chiral catalysis. The aim of this work – investigate 2,3,3-trimethyl-3H-indole and its salts reactions with sodium cyanide and to perform hydrolysis and reduction reactions with these products. Reactions of sodium cyanide with 3H-indole and its salts were successful and desired products obtained. This synthesis path is perspective way for obtaining new α-carbonitrile derivatives. In the next step reduction and hydrolysis reactions were tested on α-carbonitriles, but nitrile groups were too sensitive for reaction conditions and got eliminated. The only exception – catalytic reduction of α-carbonitriles additionally using protective Boc group. In this case carbamates were obtained. There is still plenty of possible reduction and hydrolysis reactions to try on purpose to find effective methods for convertion of α-carbonitriles. |
| Dissertation Institution |
Kauno technologijos universitetas. |
| Type |
Master thesis |
| Language |
Lithuanian |
| Publication date |
2018 |
