| Abstract [eng] |
Benzo[b]thiophene ring containing compounds are of great importance because of their diverse biological activities. These heterocyclic substances have antitumor, antioxidative, anti-inflammatory and antifungal properties. Therefore, benzo[b]thiophene derivatives are promising compounds as new drug molecules in drug design. The N-arylation of methyl 3-aminobenzo[b]thiophene-2-carboxylate with a variety of functional group substituted aryl iodides was found to be greatly simplified by inexpensive, air-stable, catalyst systems, combining catalytic copper iodide salt with a set of structurally simple L-proline ligand. Mild, efficient, copper-catalyzed Ullmann type C-N coupling procedures for mentioned heterocyclic compounds were described in this work. |
