| Title |
Naujų azetidinil-1H-pirazolo-karboksirūgščių darinių sintezė ir biologinių savybių tyrimas |
| Translation of Title |
Synthesis of novel azetidinyl-1H-pyrazole-carboxylic acids and assessment of their biological activity. |
| Authors |
Varnelis, Valentas |
| Full Text |
|
| Pages |
64 |
| Keywords [eng] |
pyrazole ; tert-butyl-3[(2E)-4-ethoxy-3-hydroxy-4-oxobut-2-enoyl]azetidine-1-carboxylate ; 3-[1-(tert-butoxycarbonyl)azetidin-3-yl]-1H-pyrazole-5-carboxylic acids ; 3-[5-(ethoxycarbonyl)-1H-pyrazol-3-yl]azetidin-1-ium chlorides ; 3-[5-carboxy-1H-pyrazol-3-yl]azetidin-1-ium chlorides |
| Abstract [eng] |
This work consists of azetidinil-1H-pirzole-carboxylic acid sythesis and its biological activity assesement. To fully examine the activity of these new acids four types of compunds were investigated. Ethyl-3-(azetidin-3-yl)-1H-pyrazole-5-carboxylates, 3-[1-(tert-butoxycarbonyl)azetidin-3-yl]-1H-pyrazole-5-carboxylic acids, 3-[5-(ethoxycarbonyl)-1H-pyrazol-3-yl]azetidin-1-ium chlorides and 3-[5-carboxy-1H-pyrazol-3-yl]azetidin-1-ium chlorides. Ethyl-3-(azetidin-3-yl)-1H-pyrazole-5-carboxylate compounds were obtained during condensation reaction with asymmetric β-diketones and monosubstituted hydrazine compounds. These azetidinyl-1H-pyrazole-ethylcarboxylates underwent hydrolysis and/ or N-Boc protecting group removal reactions to obtain previously mentioned pyrazole compunds. Structure of newly synthesized compounds were confirmed by 1H, 13C NMR, IR spectroscopy and MS, HRMS spectrometry methods. |
| Dissertation Institution |
Kauno technologijos universitetas. |
| Type |
Master thesis |
| Language |
Lithuanian |
| Publication date |
2018 |
