| Abstract [eng] |
4-Aminobutanoic acid (GABA) is one of the most import neurotrasmitters in mammalian central nervous system. It is well known that not enough of this amino acid can lead to neurological disorders such as Huntington‘s chorea, Parkinson‘s or Alzheimer‘s disease and many others. GABA analogues currently available in market are used to effectively treat a wide array of disorders, that is why creating new GABA analogues is a very important task. The primary aim of this work is to optimize synthesis conditions of conformationally restricted GABA analogues , to purify them, to characterize the obtained molecules using NMR, ATR-IR and HRMS methods, also to complete ADME analysis using bioninformatics and , by using the obtained information, to decide if the molecules are optimal for the further investigation. |
