| Abstract [eng] |
Gynaecologic malignancies are one of the important cause of mortality and morbidity among women around the world. According to Foundation of women cancer in 2015 it was estimated that over 98 000 women would be diagnosed with a gynaecologic cancer and over 30 000 will die from it. Gynaecological cancer is described as uncontrolled growth and spread of abnormal cells originating in the female reproductive organs and there are five main sources from where cancer could spread including the cervix, ovaries, uterus, fallopian tubes, vagina and vulva and all of them as a group are referred as gynaecologic cancers. Techniques which are used for the treatment depend on various factors such as treatment method, cancer type, shape, location and others. In this Master thesis treatment method using two treatment fields (main and segment) was applied for the treatment of gynaecologic cancer patients. It was aimed to deliver the planned dose to the target (tumour) and to spare ovaries from high doses since ovaries are characterized as being very sensitive to radiation. The main task implementing this method was assessment of dose delivery accuracy performing in vivo and in vitro investigations using radiochromic films and semiconductor diodes. In vitro measurements revealed that the correct positioning of a segment field has a great influence on treatment accuracy since it is related to the maximum dose which is delivered to the gynaecologic cancer patients. Based on in vitro measurements decision was made to check consistency of in vivo dose delivery according to prepared dose treatment plans for real patients. Dosimetry for 7 gynaecologic cancer patients have been performed taking into account dose delivery using two overlapping fields. The results of in vivo measurements have shown, that the relative dose errors varied within the tolerance limits indicating that patient treatment was performed correctly. |
