| Title |
Controlled external thigh compression: a feasible method to simulate venous hemodynamic alterations resembling deep vein thrombosis |
| Authors |
Eitminavičius, Rimvydas ; Jurkonis, Rytis ; Maja, Sami ; Ahola, Roni ; Balčiūnienė, Neringa ; Vehkaoja, Antti ; Marozas, Vaidotas ; Rapalis, Andrius |
| DOI |
10.1007/s10439-026-04014-y |
| Full Text |
|
| Is Part of |
Annals of biomedical engineering.. New York : Springer. 2026, Early access, p. 1-11.. ISSN 0090-6964. eISSN 1573-9686 |
| Keywords [eng] |
Deep vein thrombosis ; Light reflection rheography ; Venous hemodynamics ; Venous occlusion plethysmography ; Venous stenosis |
| Abstract [eng] |
PURPOSE: Deep vein thrombosis (DVT) poses significant health risks, including potentially fatal pulmonary embolism. Current clinical practice relies heavily on ultrasonography, requiring a skilled specialist. Alternative methods, such as light reflection rheography (LRR) and venous occlusion plethysmography (VOP), are non-invasive and simple; however, studies report limited consistency and standardization. The development of biosignal-based diagnostic tools is constrained by the inherent risks of DVT, including embolization, and challenges in patient recruitment. The ability to simulate DVT-like conditions would aid in developing and testing alternative screening methods. This study aims to present a simulation method of venous hemodynamic alterations resembling deep vein thrombosis using controlled external thigh compression with ultrasonic visualization. METHODS: Data collection with thirty healthy volunteers was conducted in a laboratory using a commercially available system VasoScreen 5000-4000 to record LRR and VOP signals. Vein stenosis at varying levels was induced through controlled external thigh compression under ultrasonic guidance. RESULTS: The experimental simulation showed statistically significant but small changes in LRR parameters across different stenosis levels. In comparison, VOP results showed greater differences across stenosis levels, with 70% and 100% performing the best. In these cases, 47% and 70% of the measurements, respectively, were below the normal reference limit, with a notably increased outflow time constant, compared to the baseline measurements, where it remained low despite varying venous capacity. CONCLUSION: Presented hemodynamic alterations demonstrated to be a feasible option for simulating DVT-like conditions via controlled external pressure on the thigh. |
| Published |
New York : Springer |
| Type |
Journal article |
| Language |
English |
| Publication date |
2026 |
| CC license |
|
