| Title |
Synthesis and evaluation of the antibacterial, antioxidant activities of novel functionalized thiazole and bis(thiazol-5-yl)methane derivatives |
| Authors |
Parašotas, Irmantas ; Anusevičius, Kazimieras ; Vaickelionienė, Rita ; Jonuškienė, Ilona ; Stasevych, Maryna ; Zvarych, Viktor ; Komarovska-Porokhnyavets, Olena ; Novikov, Volodymyr ; Belyakov, Sergey ; Mickevičius, Vytautas |
| DOI |
10.24820/ark.5550190.p010.159 |
| Full Text |
|
| Is Part of |
Arkivoc.. Gainesville, FL : ARKAT USA. 2018, vol. 2018, iss 3, p. 240-256.. ISSN 1551-7004. eISSN 1551-7012 |
| Keywords [eng] |
thiazole ; dihydroquinolone ; bis(thiazol-5-yl)methane ; antibacterial ; antioxidant activity |
| Abstract [eng] |
Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4-hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and the corresponding α-halocarbonyl compounds in good yields. A series of chemical transformations of the obtained products were carried out, and new functionalized thiazole derivatives with aliphatic, aromatic and heterocyclic substituents were synthesized. 4-Phenyl-substituted N-(4-hydroxyphenyl)-N-carboxyalkylaminothiazoles were used as precursors for the synthesis of bis(thiazol-5-yl)methane derivatives, which then were screened for their antibacterial, antioxidant activities. |
| Published |
Gainesville, FL : ARKAT USA |
| Type |
Journal article |
| Language |
English |
| Publication date |
2018 |
| CC license |
|
