| Title |
Cellulose-based scaffolds with prolonged dexamethasone release for bone tissue engineering |
| Authors |
Liesienė, Jolanta ; Baniukaitiene, Odeta ; Minseviciene, Ieva |
| DOI |
10.3390/molecules30132760 |
| Full Text |
|
| Is Part of |
Molecules.. Basel : MDPI. 2025, vol. 30, iss. 13, art. no. 2760, p. 1-13.. ISSN 1420-3049 |
| Keywords [eng] |
cellulose cationization ; cellulose-based scaffolds ; dexamethasone ; prolonged release |
| Abstract [eng] |
The implantation of bone substitutes is frequently accompanied by inflammation. To reduce the inflammatory response and enhance cell adhesion, proliferation, and differentiation, scaffolds are often loaded with anti-inflammatory drugs. In this study, cellulose and cellulose/hydroxyapatite (1:1 by weight) scaffolds were developed. Structural analysis using SEM and micro-computed tomography revealed that the morphology of the scaffolds met the requirements for bone tissue engineering. The scaffolds were initially loaded with dexamethasone sodium phosphate; however, the drug was released very rapidly. To prolong its release, cationic groups were introduced into the cellulose macromolecules by amination with 2-chloro-N,N-diethylethylamine hydrochloride in an alkaline medium. Dexamethasone sodium phosphate was then immobilised on aminated cellulose and aminated cellulose/HAp scaffolds at concentrations of 157 mg/g and 87 mg/g, respectively. Due to ionic interactions between the cationic groups in the scaffolds and the anionic groups of the drug molecules, drug release was effectively prolonged. After 24 h, only about 6–7% of the drug had been released, with complete release occurring after 170 h. The cationic groups in the scaffold framework facilitated the adsorption and sustained release of dexamethasone sodium phosphate. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
