| Title |
Pre-mRNA splicing: regulation of monoamine oxidase B and oxygen-dependent genes expression / |
| Translation of Title |
Pre-iRNR splaisingas: monoaminooksidazės B ir nuo deguonies kiekio priklausomų genų raiškos reguliacija. |
| Authors |
Jakubauskienė, Eglė |
| Full Text |
|
| Pages |
32 |
| Keywords [eng] |
monoamino oxidase B (MAO-B) ; pre-mRNA splicing ; hypoxia ; SR protein ; SR protein kinase |
| Abstract [eng] |
Pre-mRNA splicing is one of the essential steps in the regulation of the eukaryotic gene expression and the disruption of the normal splicing patterns can lead to various human diseases. We demonstrate that G/A polymorphism in intron 13 sequence of MAO-B gene regulates MAO-B protein expression levels and could serve as Parkinson disease marker. We also report that hypoxic conditions change the alternative splice site usage on pre-mRNA by changing the activity of SR proteins. Increased in SR protein phosphorylation levels in hypoxic cells are determined by the increased expression of specific SR protein kinases. Reduction of CLK1 expression in hypoxic cells promotes usage of normoxic splice sites. |
| Dissertation Institution |
Kauno technologijos universitetas. |
| Type |
Summaries of doctoral thesis |
| Language |
English |
| Publication date |
2017 |
