| Title |
Towards ultrasensitive biosensors based on virus-like particles and plasmonic surface lattice resonance / |
| Authors |
Andrzejewska, Weronika ; Khinevich, Nadzeya ; Obstarczyk, Patryk ; Murawka, Szymon ; Tamulevičius, Tomas ; Olesiak-Bańska, Joanna ; Tamulevičius, Sigitas ; Lewandowski, Mikołaj |
| DOI |
10.1016/j.bios.2025.117143 |
| Full Text |
|
| Is Part of |
Biosensors and bioelectronics.. Kidlington : Elsevier. 2025, vol. 274, art. no. 117143, p. 1-6.. ISSN 0956-5663. eISSN 1873-4235 |
| Keywords [eng] |
biosensors ; plasmonic surface lattice resonance ; Raman spectroscopy ; protein-antibody interactions ; virus-like particles ; nanoparticle arrays |
| Abstract [eng] |
Plasmonic surface lattice resonance (SLR) is a phenomenon in which individual localized surface plasmon resonances (LSPRs) excited in periodically-arranged plasmonic nanoparticles couple through the interaction with the propagating diffracted incident light. The SLR optical absorption peak is by at least one order of magnitude more intense than the LSPR one, making SLR superior for applications in which LSPR is commonly used. Recently, we have developed a route for the fabrication of spherical virus-like particles (VLPs) with plasmonic Au cores and protein coronas, where the LSPR in the cores amplifies vibrational Raman signals originating from protein-antibody interactions [ACS Synth. Biol. 12 (2023) 2320]. The particles are promising for biosensing, however, the intensity of the signals recorded in solution is not strong enough to detect antibodies at very low concentrations. Here, we show that by ordering the VLPs in periodic nanoarrays exhibiting SLR amplifies the signals by two orders of magnitude, revealing superior potential of VLP-SLR arrays in ultrasensitive biodetection. |
| Published |
Kidlington : Elsevier |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
