| Title |
Synthesis and antimicrobial evaluation of 2-[2-(9H-Fluoren-9-ylidene)hydrazin-1-yl]-1,3-thiazole derivatives |
| Authors |
Anusevičius, Kazimieras ; Stebrytė, Ignė ; Kavaliauskas, Povilas |
| DOI |
10.3390/M1872 |
| Full Text |
|
| Is Part of |
MolBank.. Basel : MDPI. 2024, vol. 2024, iss. 3, art. no. M1872, p. 1-9.. ISSN 1422-8599 |
| Keywords [eng] |
antibacterial ; antifungal ; carbothioamide ; fluorenone ; thiazoles |
| Abstract [eng] |
Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent. A base catalyst is not necessary for synthesising thiazoles, but it can shorten the reaction time. The antimicrobial properties of all synthesized compounds were screened for multidrug-resistant microorganism strains. The minimum inhibitory concentration of the tested compounds against Gram-positive bacteria and fungi was higher than 256 μg/mL, but several compounds had activity against Gram-positive strains. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
