| Title |
Synthesis and photo-induced anticancer activity of new 2-phenylethenyl-1H-benzo[e]indole dyes / |
| Authors |
Varvuolytė, Gabrielė ; Řezníčková, Eva ; Krikštolė, Sonata ; Tamulienė, Rasa ; Bieliauskas, Aurimas ; Malina, Lukáš ; Vojáčková, Veronika ; Duben, Zdenko ; Kolářová, Hana ; Kleizienė, Neringa ; Arbačiauskienė, Eglė ; Žukauskaitė, Asta ; Kryštof, Vladimír ; Šačkus, Algirdas |
| DOI |
10.1016/j.ejmech.2024.116777 |
| Full Text |
|
| Is Part of |
European journal of medicinal chemistry.. Issy-les-Moulineaux : Elsevier Masson SAS. 2024, vol. 277, art. no. 116777, p. 1-14.. ISSN 0223-5234. eISSN 1768-3254 |
| Keywords [eng] |
benzo[e]indole ; DNA damage ; Knoevenagel condensation ; photo-induced activity ; reactive oxygen species |
| Abstract [eng] |
Herein, a series of new 1,1,2-trimethyl-1H-benzo[e]indole dyes was prepared via Knoevenagel condensation reaction between 1,1,2-trimethyl-1H-benzo[e]indole and benzaldehydes, and characterized using various spectroscopic methods. The obtained compounds showed cytotoxic properties in G361 melanoma cell line upon irradiation with 414 nm blue light at submicromolar doses. The mechanism of action of the most potent compound 15 was further investigated. The treatment induced substantial generation of reactive oxygen species, leading to DNA damage followed by cell death depending on the concentration of the photosensitizer compound and the irradiation intensity. |
| Published |
Issy-les-Moulineaux : Elsevier Masson SAS |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
