| Title |
Subcritical water extraction of Vincetoxicum spp. leaves: a promising approach for isolation of antiviral compounds targeting Zika virus / |
| Authors |
Jovaišaitė, J ; Jūrienė, L ; Kalamouni, C. El ; Kukuła-Koch, W ; Szczeblewski, P ; Venskutonis, P.R |
| DOI |
10.18690/um.fkkt.2.2024 |
| ISBN |
9789612868901 |
| Full Text |
|
| Is Part of |
20th European meeting on supercritical fluids: [26-29 May 2024, Maribor, Slovenia]: book of abstracts / editors Ž. Knez, M. Pantić, D. Cör Andrejč... Maribor : University of Maribor press, 2024. p. 142-143.. ISBN 9789612868901 |
| Abstract [eng] |
Vincetoxicum is a genus of flowering plants in the family Apocynaceae, which is native to Europe and Asia [1]. Some Vincetoxicum spp. are well-known for their alkaloids, while the studies on other phytochemicals, such as phenolic acids and flavonoids, are rather scarce. Considering the widely documented health benefits (antioxidant, anticancer, anti-inflammatory, antiviral and other bioactivities), there is an interest in a more systematic evaluation of Vincetoxicum spp. (poly)phenolic and other bioactive compounds, as well as their properties. For instance, quercetin, luteolin, and r utin w ere r eported a s t he s trongest a ntiviral f lavonoids, which may have antiviral activity against numerous enveloped RNA viruses, including Flavivirus. The aim of this study was to isolate bioactive compounds from Vincetoxicum species with antiviral activity using subcritical water extraction (SWE) (Figure 1). The SWE operating conditions were 110 °C, 10.3 MPa, and 60 minutes extraction time. Also, to perform a preliminary screening of the phytochemical composition of the obtained extracts by the HPLC method. In addition, considering the possible antiviral activity of phenolic compounds against different viruses, the extract antiviral activity was evaluated against the Zika virus in vitro on human lung epithelial (A549) cells. |
| Published |
Maribor : University of Maribor press, 2024 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
