| Abstract [eng] |
In this research we analyze optimization of cells gap junctions simulation model (GJM – Gap Junction Model, designed by N. Paulauskas – Kaunas University of Technology student). The main object of study is the optimization problem. In one module of the system, using global optimization methods, is looking for the model parameters to which the model and real experiments (obtained from the New York, Yeshiva University, Albert Einstein College of Medicine Laboratory (prof. Felikso Bukausko)) results differ minimally or overlap. In this case, we are simulating cells gap junction voltage dependence of conductivity (simulating electro-physiological processes). Optimizing the model parameters of the search were collected at the results of simulation with different number of iterations (solved by Nerijus Lukšys), and the choice of different optimization methods, realized in another system. There was consulting with academic habil. dr. prof. Jonas Mockus. The results showed methods weak and strong points and their application in Grid systems. The purpose of this problem was to implement gap junction simulation model on the Grid system (solved by Algirdas Žukauskas). Use several optimization methods and compare the results. |
