| Title |
Minimizing chemotherapy side effects: calcium sonoporation / |
| Authors |
Rulinskaitė, Reda ; Palepšienė, Rūta ; Šatkauskas, Saulius ; Raišutis, Renaldas ; Maciulevičius, Martynas |
| DOI |
10.15388/Proceedings.2024.46 |
| ISBN |
9786090710517 |
| Full Text |
|
| Is Part of |
Open readings 2024: the 67th international conference for students of physics and natural sciences: book of abstracts / editors: M. Keršys, R. Naina, V. Adomaitis, E. Maskvytis.. Vilnius : Vilnius University Press, 2024. p. 300.. ISBN 9786090710517 |
| Abstract [eng] |
In chemotherapy, the main goal is to eliminate cancerous cells by inhibiting their proliferation and metastasis to other organs. Chemotherapy can lead to adverse short-term and long-term side effects such as infertility, alopecia [1]. Calcium (Ca2+) ions are significant for signal transduction pathways, due to being one of the most common intracellular signal transmitters between various signal compartments of the cell [2]. The disruption of intracellular Ca2+ homeostasis in a cell could play a crucial role in the destruction of cancer cells. It has been shown that Ca2+ serves an essential role in electroporation and demonstrates a potential for anti-cancer treatment [3]. In attaining spatio-temporally controlled delivery of anticancer drugs, sonoporation (SP) employs non-invasive application of medical ultrasound (US) in conjunction with microbubbles (MBs). SP might prove more efficacious than electroporation, however, Ca2+ delivery and application for sonotherapy has not been sufficiently studied. The utilization of Ca2+ in cancer treatment presents a promising avenue for the substantial mitigation of adverse side effects associated with conventional cytotoxic agents. [...]. |
| Published |
Vilnius : Vilnius University Press, 2024 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
