| Title |
Preparation and investigation of multi-layered orally disintegrating films / |
| Authors |
Liudvinavičiūtė, Dovilė ; Galkauskaitė, Emilija ; Navikaitė-Šnipaitienė, Vesta ; Kitrytė-Syrpa, Vaida ; Syrpas, Michail ; Rutkaitė, Ramunė |
| DOI |
10.15388/Proceedings.2024.46 |
| ISBN |
9786090710517 |
| Full Text |
|
| Is Part of |
Open readings 2024: the 67th international conference for students of physics and natural sciences: book of abstracts / editors: M. Keršys, R. Naina, V. Adomaitis, E. Maskvytis.. Vilnius : Vilnius University press, 2024. p. 243.. ISBN 9786090710517 |
| Abstract [eng] |
Oral administration of pharmaceuticals is the most preferred drug delivery method amongst patients due to its ease of administration, non-invasiveness and acceptability [1]. Orally disintegrating films (ODFs) are polymer-based, thin, flexible and pharmacologically active films, which applied to the oral mucosa begin to disintegrate/dissolve and release active components [2]. Oral diseases often require local and prolonged treatment and ODF could be considered as the best drug delivery system. ODFs can be formulated as a single- or multi-layered films, allowing controlled release of active substances. ODFs are typically obtained by solvent casting method, where casting liquid contains film forming material, solvent, plasticizer, anti-adherent, sweetener, color and flavor additives. Bio-based polymers or biodegradable polymers are gaining interest as good film forming materials for ODFs formation, due to their hydrophilic nature and non-toxicity. The aim of present study was to obtain two- and three-layer films using bio-based or biodegradable polymers as film formers for possible application for ODFs and to evaluate their mechanical and physicochemical properties. Three two-layer films and one three-layer film were obtained using poly(vinyl alcohol), 2-hydroxyethyl cellulose, methyl cellulose, chitosan, cellulose diacetate, hydroxypropyl cellulose as film forming materials by solvent casting method. Each layer of the multi-layer film contained 83.34 wt.% of polymer, 8.33 wt.% of glycerol as plasticizer and 8.33 wt.% of citric acid as cross-linker. Main characteristics of multi-layered films, such as solubility and swelling in a simulated salivary fluid, contact angle, mechanical properties were evaluated. |
| Published |
Vilnius : Vilnius University press, 2024 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
