| Title |
Functionalization and properties investigations of benzothiophene derivatives |
| Authors |
Kovševič, Arnas ; Jaglinskaitė, Indrė ; Kederienė, Vilija |
| DOI |
10.15388/Proceedings.2024.46 |
| ISBN |
9786090710517 |
| Full Text |
|
| Is Part of |
Open readings 2024: the 67th international conference for students of physics and natural sciences: book of abstracts / editors: M. Keršys, R. Naina, V. Adomaitis, E. Maskvytis.. Vilnius : Vilnius University Press, 2024. p. 203.. ISBN 9786090710517 |
| Abstract [eng] |
Due to their diverse biological properties, benzo[b]thiophenes are heterocyclic compounds widely used in pharmaceuticals. Benzo[b]thiophene derivatives have anti-allergic, antibacterial, and anti-inflammatory effects. They are receptor modulators and antioxidants. [1] It has been established that benzo[b]thiophene derivatives can be potential drugs in cancer treatment, as the inhibition of protein tubulin polymerization and cell proliferation characterizes them. [2] The drugs Raloxifene, intended for the treatment of osteoporosis during postmenopause, and Zileuton, an antiasthmatic drug, are based on them. [1] In addition, benzo[b]thiophene compounds are used in solar cells and thin-film devices due to their fluorescent properties. [3] N-substituted benzo[b]thiophene derivatives are also used in the pharmaceutical industry because of their biological properties, such as antifungal, antibacterial and anti-inflammatory properties. [4] In addition, the drug Encenicline was discovered, which is active against schizophrenia and Alzheimerś disease. [1] Also, these compounds are not only biologically active substances but also have luminescent properties so that they can act as efficient emitters. [5] For further synthesis, benzo[b]thiophene derivatives were chosen due to their wide application. After choosing the optimal conditions at the beginning of the study, the initial derivative of 3-aminobenzo[b]thiophene was synthesized. Various reaction methodologies were employed to investigate the reactivity of 3- aminobenzo[b]thiophene-2-methylcarboxylate with different substituents. A detailed analysis was conducted on the structure of the 3-aminobenzo[b]thiophene derivatives obtained. [...]. |
| Published |
Vilnius : Vilnius University Press, 2024 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
