| Abstract [eng] |
In this paper the methodology of composing of Markov models of the gap junction of cells is introduced. This methodology contains of computing of transition probabilities using scheme of independent J. Bernoulli trials, computing of stationary probabilities and computing of the conductance of the gap junction dependence on a voltage. It is considered that the gap junction consists of a lot of channels (for example, 1000), joined parallel with each other. Each channel consists of two subchannels (connexons), joined in series, and each connexon consists of 6 units (connexins), joined parallel with each other. Each connexin can be in an open or a closed state. State of a connexin depends on a voltage that is going through the channel. The adequacy of models that were created using this methodology is tested comparing the results of modelling of the gap junction using Markov chains with the results of the imitational modelling (programs that were done by Nerijus Paulauskas and Saulius Vaičeliūnas (postgraduate students from Informatics faculty, KTU)). The latter results were tested with the results of experiments. In this paper the methodology of created Markov models was used creating the models of gap junction, where a connexin is described being in 3 states: closed, open and deep closed. |
