| Abstract [eng] |
In this paper methology of composing Markov preocess models of gap junction cells is introduced. This methology contains state graphs generation, computing of stationary probabilities and computing of the conductance of the gap junction dependence on a voltage. In this paper different gap junction models are presented. Every model has it‘s own connexin state graphs, on which the conductance of the gap junction dependence on a voltage simulation is based. Every connexin can have two different state scenarios: first scenario where two connexin model is based on two states „O“ – open or „C“ – closed and second scenario where three connexin model is based on three states „O“ – open, „C“ – closed and „D“ – deep closed. The computer programs based on these models where created, which allows user graphically see the models state graphs, simulate models and get the needed results. Also these programs are integrated into more difficult systems and into other libraries. |
