| Title |
Cascade cyclisation of pyrazole-4-carbaldehydes and phenylendiamines: access to novel pyrazolooxazepanes / |
| Authors |
Užupytė, Agnė ; Antulytė, Gabrielė ; Arbačiauskienė, Eglė ; Šačkus, Algirdas |
| DOI |
10.15388/IOR2023 |
| ISBN |
9786090708835 |
| Full Text |
|
| Is Part of |
Open readings 2023: 66th international conference for students of physics and natural sciences, April 18-21, 2023, Vilnius, Lithuania: annual abstract book / editors: M. Keršys, Š. Mickus.. Vilnius : Vilnius University press, 2023. p. 152.. ISBN 9786090708835 |
| Abstract [eng] |
Cascade reactions are described as multiple organic transformations happening one after the other without changing the reaction conditions in a single flask. [1] These reactions fall into the category of ‘green’ or sustainable chemistry as they are known for their atom economy, as well as show economies of time, labor, resource management and waste generation [2,3]. The successful application of cascade reactions has led to the efficient synthesis of various complex natural products and organic scaffolds [4]. Fused pyrazole-based heterocyclic compounds are integrated into everyday life, including pharmaceuticals [5], agrochemicals [6], various functional materials [7]. These compounds exhibit wide spectrum of biological properties, including antioxidant, antimicrobial, and antiproliferative activities [8]. In this work, we present a cascade synthesis approach to obtain novel benzo[4,5]imidazo[1,2-d]pyrazolo[4,3- f][1,4]oxazepines starting from easily accessible pyrazole-4-carbaldehydes and phenylendiamines. A one-pot two-step process was found to be highly atom economical, simply and enabled the generation of novel polycyclic system in good yield. The structures of novel fused heterocyclic compounds were confirmed by 1H, 13C, and 15N-NMR spectroscopy. |
| Published |
Vilnius : Vilnius University press, 2023 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
