| Is Part of |
Open readings 2023: 66th international conference for students of physics and natural sciences, April 18-21, 2023, Vilnius, Lithuania: annual abstract book / editors: M. Keršys, Š. Mickus.. Vilnius : Vilnius University press, 2023. p. 137.. ISBN 9786090708835 |
| Abstract [eng] |
Numerous studies have revealed that bioactive substances have drawn significant interest due to their wide array of potential uses in various spheres of life, including food, engineering, and the biomedical sector. However, such bioactive compounds limited practical applicability and decreased bioavailability are caused by their low water solubility, instability under light and heating conditions, and other considerations. Nanocapsules, emulsions, and micelles might enhance the half-life of drugs in vivo and in vitro while overcoming the drawbacks of their instability. Dextrin, a primary degradation product of starch, exhibits non-Newtonian fluid properties in solution and has excellent properties such as water-solubility, emulsibility, dispersibility, adhesion and film-forming properties. Compared to native starch, dextrin can be more easily modified by octenyl succinic anhydride (OSA) due to its low molecular weight. Moreover, it’s known that OSA modified dextrin possess excellent emulsifying properties and could be exploited for the immobilisation of bioactive substances [1, 2]. This study aimed to explore preparation of octenyl succinic anhydride modified dextrins and to study their emulsifying properties. OSA modified dextrins were synthesized by esterification of potato dextrin with OSA in aqueous solution (see scheme in Fig. 1). The amount of OSA added was 3, 6, 9 and 12 percent of the weight of dextrin while maintaining the pH at 8 using NaOH solution. By changing the amount of OSA, four different hydrophobically modified dextrin derivatives were prepared. [...]. |
