| Is Part of |
Open readings 2023: 66th international conference for students of physics and natural sciences, April 18-21, 2023, Vilnius, Lithuania: annual abstract book / editors: M. Keršys, Š. Mickus.. Vilnius : Vilnius University press, 2023. p. 132.. ISBN 9786090708835 |
| Abstract [eng] |
One of the most progressive pathologies in the world is various oral cavity infections. They are associated with the worsening quality of life and increasing health costs [1]. Developing the new ways to treat these diseases are very important. Oral disintegrating films (ODF) are thin, flexible films made of hydrophilic polymers, pharmacologically active substances, plasticizers, flavorings, dyes and sweeteners [2, 3]. There are many reports on films that quickly disintegrate in the oral mucosa and immediately release biologically active components into the systemic circulation. However, self-disintegrating films with prolonged activity are still underexplored and could be effective method for the local treatment of periodontal diseases, caries, stomatitis, and other infections in the oral cavity. The main goal of this research work was the formation of ODFs from natural polysaccharide derivatives and natural plant extracts and investigation of their properties. Polymeric films of various composition were formed by solvent casting method using natural polysaccharide derivatives - chitosan, hydroxyethylcellulose, hydroxypropylmethylcellulose, plasticizer glycerin and crosslinking agent citric acid, in which the extracts of hop and birch leaves were immobilized. The mechanical, thermal, hydrophobic and water vapor permeability properties of the various films were evaluated. The solubility in various aqueous solutions was determined. The films of hydroxyethylcellulose were the most elastic and the least rigid. Immobilization of plant extracts reduced the tensile strength and modulus of elasticity of the polymeric films. The water wetting angle of the films of various composition ranged from 42.3 to 86.3 degrees. In films containing plant extracts wetting angle increased from 80 to 86°. The films of natural polysaccharide derivatives formed using citric acid had the lowest solubility in distilled water, with a water solubility being less than 25 percent after 7 days. Films containing birch leaf extract showed higher water vapor sorption, which was equal to 72.5 percent after 72 hours, while the moisture sorption of the films containing hop extract was less than 35 percent. Meanwhile, the solubility of the films containing natural plant extracts in saliva simulant solution after 7 days was less than 32 percent. [...]. |
