| Title |
Synthesis and chemical properties of 3-(1-(4-methoxy-2-nitrophenyl)thioureido)propanoic acid / |
| Authors |
Gelminauskaitė, Roberta ; Grybaitė, Birutė ; Mickevičius, Vytautas |
| DOI |
10.15388/IOR2023 |
| ISBN |
9786090708835 |
| Full Text |
|
| Is Part of |
Open readings 2023: 66th international conference for students of physics and natural sciences, April 18-21, 2023, Vilnius, Lithuania: annual abstract book / editors: M. Keršys, Š. Mickus.. Vilnius : Vilnius University press, 2023. p. 130.. ISBN 9786090708835 |
| Abstract [eng] |
Thiazole ring is commonly used as functional group to enhance the bioactivity of related pharmacophores, which mostly emerged as a substructure in a large class of β-lactam antibiotics. Thiazolones, one series of thiazole derivatives, exist widely in bioactive natural compounds and exhibit various biological properties such as antitumor, antibiotic and has been used in a variety of commercially available drugs to treat diseases like inflammation and hypertension. [1-3] New studies shows that thiazole derivatives, containing differently substituted phenyl ring, can be used as an antidiabetic agent against diabetes mellitus chronic metabolic disease. Pharmaceutically thiazole scaffold derivatives are well known, especially in number of anticancer compounds, displaying activities against a variety of tumor cell lines, including non-small cell lung cancer, human colon cancer and human breast adenocarcinoma. Besides that, they have also been proven to be potent inhibitors of cyclin-dependent kinases targets. These medicinal properties states that thiazole derivatives can be encouraging candidates for further drug development. [4,5] [...]. |
| Published |
Vilnius : Vilnius University press, 2023 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
