| Title |
Synthesis and chemical properties of 1-(2-hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid / |
| Authors |
Krikštaponis, Karolis ; Grybaitė, Birutė |
| DOI |
10.15388/IOR2023 |
| ISBN |
9786090708835 |
| Full Text |
|
| Is Part of |
Open readings 2023: 66th international conference for students of physics and natural sciences, April 18-21, 2023, Vilnius, Lithuania: annual abstract book / editors: M. Keršys, Š. Mickus.. Vilnius : Vilnius University press, 2023. p. 126.. ISBN 9786090708835 |
| Abstract [eng] |
Pyrrolidinone derivatives exhibit various pharmacological properties: antibacterial, antioxidant, anti-cancer, antifungal, antiviral and anticonvulsant [1, 2]. Many examples of drugs such as piracetam, metadoxine, rolipram, raltegravir are known, the active ingredient of which is a pyrrolidinone derivative [3]. Therefore, in this study synthesized novel pyrrolidinone derivatives could be potential bioactive compounds in the discovery of new candidate drugs. To further improve the biological properties, other bioactive moieties were introduced into molecular structures [4]. This includes pyrazole, pyrrole and other heterocyclic scaffolds. The desired compounds were prepared by multi-step synthesis process as shown in figure 1. [...]. |
| Published |
Vilnius : Vilnius University press, 2023 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
