| Abstract [eng] |
In this work synthesis reaction of 1- (5-chloro-2-hydroxyphenyl)-5-oxopyrrolidin-3-carbohydrazide and its addition reactions with methyl-, phenyliso(thio)cyanate, condensation reactions with aromatic aldehyde and aliphatic diketones were conducted in order to get semi(thio)carbazides, 1,2,4-triazole and hydrazone derivantives. Was make on 1,2,4-triazole S-alkylation reaction. The structure of synthesized compounds was confirmed by 1H NMR, 13C NMR and mass spectroscopy. Biological activity of the synthesized compounds was studied by the method of laboratory monitoring. The rezults showed that 3-[1-(5-chloro-2-hydroxyphenyl)-5-oxopyrrolidin-3-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one and 1-(5-chloro-2-hydroxyphenyl)-4-(5-sulfanylidene-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyrrolidin-2-one had the best antioxidant activity and 1-(5-chloro-2-hydroxyphenyl)-N-{[(4-chlorophenyl) carbamoyl]amino}-5-oxopyrrolidine-3-carboxamideshowed the best reduction properties. Technological production line of 1-(5-chloro-2-hydroxyphenyl)-4-(5-sulfanylidene-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyrrolidin-2-one was prepared. |
