| Title |
Funkcionalizuotų N-(1-naftil)-N-(1,3-tiazol-2-il)-β-alaninų sintezė ir savybės / |
| Translation of Title |
Synthesis and properties of functionalized N-(1-naphthyl)-N-(1,3-thiazol-2-yl)-β-alanines. |
| Authors |
Grybaitė, Birutė |
| Full Text |
|
| Pages |
79 |
| Keywords [eng] |
N-substituted amino acids ; β-alanine ; thiazole ; thiazolone ; chalcone |
| Abstract [eng] |
Natural and synthetic N-substituted amino acids and their derivatives are often characterized by antimicrobial and plant growth stimulating effects. The aim of this work was to synthesize new potentially biologically active N,N-disubstituted β-amino acids bearing aromatic thiazole fragments in their structure and investigate their properties. N-(1-Naphthyl)-N-thiocarbamoyl-β-alanine was synthesized and its reactions with monochloroacetic acid, oxalic acid dichloride and α-haloketones were investigated. Some of the synthesized compounds were screened for antibacterial activity against Rhizobium radiobacter and Xanthomonas campestris to reveal that functionalized oxathiazole and thiazole derivatives exhibit antibacterial activity. |
| Dissertation Institution |
Kauno technologijos universitetas. |
| Type |
Master thesis |
| Language |
Lithuanian |
| Publication date |
2016 |
