| Title |
Design of 5-substituted 2-oxindole-hydrazone derivatives bearing 1,2,4-triazole-3-thiol moiety as anticancer agents / |
| Authors |
Šermukšnytė, A ; Petrikaitė, V ; Kantminienė, K ; Jonuškienė, I ; Tumosienė, I |
| DOI |
10.15388/CCT.2023 |
| ISBN |
9786090708330 |
| Full Text |
|
| Is Part of |
Chemistry and chemical technology: international conference CCT-2023, March 10, 2023, Vilnius: conference book.. Vilnius : Vilnius university press, 2023. P 078, p. 115.. ISBN 9786090708330 |
| Abstract [eng] |
Cancer is a malignant disease characterized by rapid and uncontrolled cell proliferation. It is one of the leading causes of mortality, accounting for vast morbidity worldwide [1]. Cytotoxic drugs are among the most important treatments used for cancer; however, their permeability and efficiency are low. The search for new effective anticancer agents with superior selectivity towards cancer cells is of crucial importance. Isatin derivatives have been widely recognized in cancer therapeutics as protein kinase inhibitors. Hybrid 2-oxindole derivatives bearing the hydrazone moiety have been shown to exhibit good activity against various tumour cells (colon, leukemia, breast, and kidney) [2]. [...]. |
| Published |
Vilnius : Vilnius university press, 2023 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
