| Title |
Synthesis of new 1-(9-ethylcarbazol-3-yl)-5-oxopyrrolidine-3-carbohydrazide derivatives / |
| Authors |
Mieliauskaitė, E ; Sapijanskaitė-Banevič, B ; Vaickelionienė, R ; Grybaitė, B ; Anusevičius, K |
| DOI |
10.15388/CCT.2023 |
| ISBN |
9786090708330 |
| Full Text |
|
| Is Part of |
Chemistry and chemical technology: international conference CCT-2023, March 10, 2023, Vilnius: conference book.. Vilnius : Vilnius university press, 2023. P 071, p. 108.. ISBN 9786090708330 |
| Abstract [eng] |
In this work, 1-(9-ethylcarbazol-3-yl)-5-oxopyrrolidine-3-carbohydrazide 1 was used as a precursor for the synthesis of 5-oxopyrrolidine derivatives containing fragments of hydrazone, pyrrole, triazolethione, 1,2,4- triazine, and pyrrolidinone. In the first stage of this study a series of heterocyclic compounds was prepared. For 1,3,4-oxadiazole 2, hydrazide 1 was treated with carbon disulphide in alkaline methanolic solution. The reaction proceeded via an intermediate hydrazinocarbothioate whose aqueous solution was acidified with hydrochloric acid to pH 1 to obtain the target compound 2. The condensation of hydrazide 1 with hexane-2,5-dione in propan-2-ol in the presence of a catalytic amount of acetic acid gave 2,5-dimethylpyrrole 3. To obtain 4-phenyl-1,2,4-triazole 5, thiosemicarbazide 4 was first synthesized by refluxing hydrazide 1 with phenylisothiocyanate in the mixture of methanol and 1,4-dioxane for 7 h. The conversion of tiosemicarbazide 4 to triazole 5 was carried out in refluxing aqueous 2 KOH solution with the subsequent acidification of the reaction mixture with hydrochloric acid to pH 2. [...]. |
| Published |
Vilnius : Vilnius university press, 2023 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
