| Abstract [eng] |
The incorporation of fluorine into organic molecules can dramatically alter their reactivity, chemical and biological properties, and physiological activity. The main aim of the work: synthesis of new, potentially biologically active fluorine-containing N-aryl-β- and β,γ-amino acids, their derivatives and cyclization products, and the investigation of the structure and characteristics of the synthesized compounds. A new approach to the synthesis of 1-substituted dihydropyrimidin-2,4(1H,3H)-diones and their 2-thioanalogues was proposed. For the first time 3-[(4-fluorophenyl)carbamothioylamino]propanoic acid was used for the synthesis of thiazole derivatives. Studies of the antimicrobial activity of the synthesized compounds revealed potentially new compounds with antibacterial activity against Staphylococcus aureus and Mycobacterium luteum. Various chemical transformations of the 1-(substituted phenyl)-5-oxopyrrolidine-3-carboxylic acid were carried out. |
