| Title |
Synthesis and characterization of novel heterocyclic chalcones from 1-phenyl-1H-pyrazol-3-ol / |
| Authors |
Urbonavičius, Arminas ; Fortunato, Graziana ; Ambrazaitytė, Emilija ; Plytninkienė, Elena ; Bieliauskas, Aurimas ; Milišiūnaitė, Vaida ; Luisi, Renzo ; Arbačiauskienė, Eglė ; Krikštolaitytė, Sonata ; Šačkus, Algirdas |
| DOI |
10.3390/molecules27123752 |
| Full Text |
|
| Is Part of |
Molecules.. Basel : MDPI. 2022, vol. 27, iss. 12, art. no. 3752, p. 1-32.. ISSN 1420-3049 |
| Keywords [eng] |
1,2-oxazole (isoxazole) ; 15N-labeled 1,2-oxazole ; Claisen–Schmidt condensation ; heterocyclic chalcones ; pyrazole ; pyridine |
| Abstract [eng] |
An efficient synthetic route to construct diverse pyrazole-based chalcones from 1-phenyl-1H-pyrazol-3-ols bearing a formyl or acetyl group on the C4 position of pyrazole ring, employing a base-catalysed Claisen-Schmidt condensation reaction, is described. Isomeric chalcones were further reacted with N-hydroxy-4-toluenesulfonamide and regioselective formation of 3,5-disubstituted 1,2-oxazoles was established. The novel pyrazole-chalcones and 1,2-oxazoles were characterized by an in-depth analysis of NMR spectral data, which were obtained through a combination of standard and advanced NMR spectroscopy techniques. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2022 |
| CC license |
|
