| Title |
Mild copper-catalyzed, l-proline-promoted cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate / |
| Authors |
Kederienė, Vilija ; Jaglinskaitė, Indrė ; Voznikaitė, Paulina ; Rousseau, Jolanta ; Rollin, Patrick ; Šačkus, Algirdas ; Tatibouët, Arnaud |
| DOI |
10.3390/molecules26226822 |
| Full Text |
|
| Is Part of |
Molecules.. Basel : MDPI. 2021, vol. 26, iss. 22, art. no. 6822, p. 1-8.. ISSN 1420-3049 |
| Keywords [eng] |
N-arylation ; aryl iodides ; benzo[b]thiophene ; copper catalysis ; l-proline |
| Abstract [eng] |
Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon-nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of (hetero)aryl iodides using CuI, l-proline and Cs2CO3 in dioxane at moderate temperature is described. The procedure is an extremely general, relatively cheap, and experimentally simple way to afford the N-substituted products in moderate to high yields. The structures of the new heterocyclic compounds were confirmed by NMR spectroscopy and HRMS investigation. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2021 |
| CC license |
|
